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Pyridoxamine - Printable Version

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Pyridoxamine - ChasingGoodandEvil - 09-26-2018

Was thinking about ordering some pyridoxamine from my chinese friends. Before i ask ray about itx does anyone have an opinion on forms of b6? I heard pyridoxamine doesnt have risks of neuropathy at higher doses.


RE: Pyridoxamine - dinosaursarecool - 09-26-2018

Haven’t tried it but I’d be skeptical of that statement about it not causing neuropathy at higher dosages. Multiple people said that about p5p (compared to pyroxidine hcl) but it certainly does. Rays dosing recommendation of 10mg max is right on the money for either p5p of pyroxidine hcl but I stick to 5mg usually just to be safe (partially because I usually use p5p and it’s said to be more potent and/or more bioavailable).


RE: Pyridoxamine - ChasingGoodandEvil - 09-26-2018

(09-26-2018, 12:10 PM)dinosaursarecool Wrote: Haven’t tried it but I’d be skeptical of that statement about it not causing neuropathy at higher dosages. Multiple people said that about p5p (compared to pyroxidine hcl) but it certainly does. Rays dosing recommendation of 10mg max is right on the money for either p5p of pyroxidine hcl but I stick to 5mg usually just to be safe (partially because I usually use p5p and it’s said to be more potent and/or more bioavailable).

I was reading from a 1940s paper that pyridoxine is actually a very minor constituent of b6 in animalsx whereas in plants it's the main vitamer. Since pyridoxamine is bannedx i naturally think it must be good .. but im going to try the pyridoxal once my sleep improves (its been fucked up from the pyridoxine). I would like to experiement with mixtures of pyridoxal and pyridoxamine, because those are the main forms in animal tissue.


RE: Pyridoxamine - sm1693 - 09-27-2018

Wow I didn't know of a different b6 compound, nor of its banning. What a disgraceful agency the FDA is.

Available b6 supplements have always seemed pretty ineffective to me.


RE: Pyridoxamine - ChasingGoodandEvil - 09-27-2018

(09-27-2018, 04:26 PM)sm1693 Wrote: Wow I didn't know of a different b6 compound, nor of its banning. What a disgraceful agency the FDA is.

Available b6 supplements have always seemed pretty ineffective to me.

Yeah i found some in china i might try, but if course it's expensive thanks to the fda. Amazoniac on the other forum referenced that zinc and niacin are important cofactors for the enzymes that convert b6, as well as riboflavin. It'd be nice to figure out why the b6 doesnt work or cause side effects. I asked ray we'll see if he knows anything. Naturally, im curious to try the banned version.


RE: Pyridoxamine - ChasingGoodandEvil - 09-29-2018

This paper says thay pyridoxine binds to, but doesnt activate, transaminase enzymes, whereas the other vitamers do. https://academic.oup.com/hmg/article/24/19/5500/584016